|
KMID : 0357119930150010053
|
|
Korean Journal of Immunology
1993 Volume.15 No. 1 p.53 ~ p.60
|
|
|
The Influence of Linoleic acid and Ursolic acid on Mouse Peritoneal Macrophage Activity
|
|
Jeong Joon-Heon
Kim Kwang-Hyuk
Jang Myung-Woong
Lee Sung-Do
Seo Jae-Kwan
|
|
|
Abstract
|
|
|
Several studies have shown that linoleic acid (LA) and ursolic acid (UA) extracted from yellowgreen vegetables reveal antitumor activities. In the present study we investigated the effect of LA and UA for the cytotoxic activity of mouse
peritoneal macrophage in order to elucidate the immunological mechanism of antitumor activity of these substances.
The peritoneal macrophage macrophage activity was significantly augmented by LA and low concentration of UA both invifro. The effect of LA appeared to be proportional to its concentration, however the effect of UA showed slightly an inhibitor effect at a high concentration (2.50μg/ml, 5.00μg/ml). Similar augmentations of peritoneal macrophage were obtained with culture supernatants of LAA or UA-exposed spleen cells and peripheral blood mononuclear cells. Marked augmentations of macrophage activities by LA and UA suggest that these materials may act as a biological response modifier.
|
|
|
KEYWORD
|
|
|
Linoleic acid, Urosolic acid, Macrophage activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|